Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 16/20 | 0.84 |
| ▸ | PDPK1 | O15530 | 13/20 | 0.84 |
| ▸ | AURKA | O14965 | 5/20 | 0.82 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.82 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667366 | 1.00 | RPS6KB1 (0.84) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL665369 | 0.91 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL665370 | 0.91 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL667402 | 0.90 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL667260 | 0.90 | RPS6KB1 (0.80) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL16476093 | 0.90 | RPS6KB1 (0.80) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL667401 | 0.90 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL667617 | 0.89 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL16460306 | 0.89 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKAAURKBCHEK1 | |
| SCHEMBL667121 | 0.89 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKAAURKBCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040560-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2015-05-26 | — | — | US | disclosed |
| US-9040560-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2015-05-26 | — | — | US | disclosed |
| US-9040560-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2015-05-26 | — | — | US | disclosed |
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2014-04-17 | — | — | US | disclosed |
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2014-04-17 | — | — | US | disclosed |
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2014-04-17 | — | — | US | disclosed |
| US-8637532-B2 | Amino azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2014-01-28 | — | — | US | disclosed |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107156-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | RPS6KB1 500/4885PDPK1 2787/4885AURKA 600/4885 |
| US-20120046269-A1 | Novel Amino Azaheterocyclic Carboxamides | AZI2, MKI67, MYC | RPS6KB1 500/4885PDPK1 2787/4885AURKA 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.