Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782805 | 0.82 | CDC7 (0.48) | TNKSDAO | |
| SCHEMBL15758398 | 0.78 | GRIA1 (0.57) | TNKSPRMT5WDR77ALDH1A1KDM4E | |
| SCHEMBL16456296 | 0.76 | TNKS (0.55) | TNKSTGFBR1PRMT5WDR77NPC1 | |
| SCHEMBL687843 | 0.76 | GRIA1 (0.58) | TNKSPRMT5WDR77ALDH1A1KDM4E | |
| SCHEMBL16455996 | 0.73 | TNKS (0.53) | TNKSPDK2PRMT5WDR77NPC1 | |
| SCHEMBL1882316 | 0.73 | AURKA (0.50) | TNKSPARP1TGFBR1PRMT5WDR77 | |
| SCHEMBL6675174 | 0.72 | HTT (0.39) | TNKSPARP1TGFBR1SMN1; SMN2NPC1 | |
| SCHEMBL1888457 | 0.71 | PRMT5 (0.43) | TNKSPRMT5PDK1WDR77COMT | |
| SCHEMBL10819097 | 0.71 | TTK (0.60) | TNKSPRMT5WDR77SMN1; SMN2NPC1 | |
| SCHEMBL13376040 | 0.71 | PRMT5 (0.43) | TNKSPRMT5PDK1WDR77COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |