Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | TXN | P10599 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | STK17B | O94768 | 2/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211352 | 0.84 | MEN1 (0.66) | MEN1KMT2ACDK1IGF1RAURKA | |
| SCHEMBL6923416 | 0.83 | CTSC (0.53) | MEN1KMT2AAURKATXNPIN1 | |
| SCHEMBL1774193 | 0.83 | IGF1R (0.68) | MEN1KMT2ACDK1IGF1RGSK3B | |
| SCHEMBL15584950 | 0.81 | AURKA (0.47) | MEN1KMT2AAURKATXNPIN1 | |
| SCHEMBL16685087 | 0.81 | AURKA (0.47) | MEN1KMT2AAURKATXNPIN1 | |
| SCHEMBL15146279 | 0.81 | AURKA (0.47) | MEN1KMT2AAURKATXNPIN1 | |
| SCHEMBL22719010 | 0.80 | MEN1 (0.61) | MEN1KMT2AIGF1RAURKA | |
| SCHEMBL29535612 | 0.80 | MEN1 (0.61) | MEN1KMT2AIGF1RAURKA | |
| SCHEMBL30749092 | 0.78 | MEN1 (0.55) | MEN1KMT2ACDK1IGF1RGSK3B | |
| SCHEMBL16684757 | 0.77 | CYP1A2 (0.50) | MEN1KMT2AAURKATXNKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004046118-A2 | 2-4-(DI-PHENYL-AMINO)-PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |
| WO-2004039359-A2 | USE OF PYRIMIDINE DERIVATES FOR THE MANIFACTURE OF A MEDICAMENT FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-05-13 | — | — | WO | disclosed |
| WO-2003095448-A1 | PYRIDINYL AMINO PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-11-20 | — | — | WO | disclosed |