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SCHEMBL6675352

SCHEMBL6675352

Cn1cc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)cc1OC(=O)NCc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ MTTP P55157 15/20 0.51
▸ APOB P04114 3/20 0.47
▸ SLC6A5 Q9Y345 1/20 0.43
▸ PPARA Q07869 1/20 0.43
▸ ADAMTS5 Q9UNA0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6674719 0.91 MTTP (0.49) MTTPAPOB
SCHEMBL7253319 0.90 MTTP (0.50) MTTPAPOB
SCHEMBL7252903 0.89 MTTP (0.50) MTTPAPOB
SCHEMBL7039224 0.89 MTTP (0.52) MTTPAPOBPPARAADAMTS5
SCHEMBL7256228 0.89 MTTP (0.49) MTTPAPOB
SCHEMBL6673894 0.89 MTTP (0.49) MTTPAPOB
SCHEMBL6685186 0.89 MTTP (0.49) MTTPAPOB
SCHEMBL6680330 0.89 MTTP (0.49) MTTPAPOB
SCHEMBL6673398 0.88 MTTP (0.49) MTTPAPOB
SCHEMBL6675663 0.88 MTTP (0.49) MTTPAPOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465613-A2 COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS Boehringer Ingelheim Pharma GmbH & Co. KG (DE) 2004-10-13 — — EP disclosed
WO-2003057205-A2 COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2003-07-17 — — WO disclosed