Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | PRKX | P51817 | 1/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407266 | 0.86 | MAPK14 (0.76) | MAPK14MAPK11CYP2C9ROCK2ROCK1 | |
| SCHEMBL6658772 | 0.85 | MAPK14 (0.74) | MAPK14MAPK11CYP2C9ROCK2ROCK1 | |
| SCHEMBL5111085 | 0.82 | MAPK14 (0.70) | MAPK14MAPK11CYP2C9HSPB1ROCK2 | |
| SCHEMBL5105839 | 0.81 | MAPK14 (0.69) | MAPK14MAPK11CYP2C9HSPB1ROCK2 | |
| SCHEMBL5106068 | 0.81 | MAPK14 (0.68) | MAPK14MAPK11CYP2C9HSPB1 | |
| SCHEMBL6575551 | 0.81 | MAPK14 (0.71) | MAPK14MAPK11CYP2C9HSPB1ROCK2 | |
| SCHEMBL3524006 | 0.81 | MAPK14 (0.67) | MAPK14MAPK11CYP2C9HSPB1ROCK2 | |
| SCHEMBL5102827 | 0.80 | MAPK14 (0.69) | MAPK14MAPK11CYP2C9HSPB1 | |
| SCHEMBL5630096 | 0.80 | MAPK14 (0.87) | MAPK14MAPK11CYP2C9HSPB1 | |
| SCHEMBL5632303 | 0.79 | MAPK14 (0.86) | MAPK14MAPK11CYP2C9HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435933-A1 | 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032970-A1 | 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |