Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28067094 | 0.89 | GAA (0.67) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL17182521 | 0.86 | GAA (0.69) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL16372649 | 0.86 | MAPT (0.74) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL28003049 | 0.85 | GAA (0.67) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL27756766 | 0.84 | TAAR1 (0.70) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL1926207 | 0.83 | MAPT (1.00) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL10296310 | 0.83 | GAA (0.65) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL17537955 | 0.82 | KDM4E (0.72) | TSHRMAPK1TAAR1HTR2AHTR2C | |
| SCHEMBL17769110 | 0.82 | TAAR1 (0.59) | TAAR1ADRA1AHTR2AHTR2C | |
| SCHEMBL626051 | 0.82 | TAAR1 (0.73) | TAAR1ADRA1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101189237-A | Tetrahydro-pyridoazepin-8-ones and related compounds for the treatment of schizophrenia | WARNER LAMBERT CO (US) | 2008-05-28 | — | — | CN | disclosed |
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| CN-1310169-A | Anils with nitric oxide synzyme inhibiting function | SHUGAI SEIYAKU K K (JP) | 2001-08-29 | — | — | CN | disclosed |
| CN-1172473-A | Aniline derivatives having nitric oxide synthase inhibitory activity | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1998-02-04 | — | — | CN | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |