Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Ethyne. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyne SCHEMBL667649 | 1.00 | — | — | |
| Ethyne SCHEMBL31067704 | 1.00 | — | — | |
| Ethyne SCHEMBL9088715 | 1.00 | — | — | |
| Ethyne SCHEMBL7632731 | 1.00 | — | — | |
| Ethyne SCHEMBL11861627 | 0.87 | — | — | |
| Ethyne SCHEMBL1072332 | 0.87 | — | — | |
| Ethyne SCHEMBL9302185 | 0.87 | — | — | |
| Ethyne SCHEMBL4753041 | 0.82 | — | — | |
| Ethyne SCHEMBL144006 | 0.82 | — | — | |
| Ethyne SCHEMBL428 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021054927-A2 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2021-03-25 | — | — | WO | claimed |
| US-20200048305-A1 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2020-02-13 | — | — | US | claimed |
| US-9622969-B2 | Polymer conjugated protein micelles | SOUTH DAKOTA STATE UNIV (US) | 2017-04-18 | — | — | US | claimed |
| US-20140370110-A1 | POLYMER CONJUGATED PROTEIN MICELLES | SOUTH DAKOTA STATE UNIVERSITY (US) | 2014-12-18 | — | — | US | claimed |
| US-4248793-A | REACTING WITH SULFUR TRIOXIDE, NEUTRALIZATION, EXTRACTION, HYDROLYSIS | THE LION FAT & OIL CO., LTD. (JP) | 1981-02-03 | — | — | US | claimed |
| CN-113698335-A | Specific conjugation of cell binding molecules | 杭州多禧生物科技有限公司 | 2021-11-26 | — | — | CN | disclosed |
| EP-2214716-B1 | HYDROXYAPATITE-TARGETING MULTIARM POLYMERS AND CONJUGATES MADE THEREFROM | NEKTAR THERAPEUTICS (US) | 2021-11-17 | — | — | EP | disclosed |
| WO-2021054927-A2 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2021-03-25 | — | — | WO | disclosed |
| US-10668161-B2 | Therapeutic hyperbranched polyglycerol encapsulated biomolecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-02 | — | — | US | disclosed |
| US-20200048305-A1 | GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS | SOUTH DAKOTA BOARD OF REGENTS (US) | 2020-02-13 | — | — | US | disclosed |
| US-20190021999-A1 | EXTREMELY SMALL NANOPARTICLES OF DEGRADABLE POLYMERS | PHOSPHOREX, INC. | 2019-01-24 | — | — | US | disclosed |
| EP-3337455-A1 | EXTREMELY SMALL NANOPARTICLES OF DEGRADABLE POLYMERS | Phosphorex Inc. (US) | 2018-06-27 | — | — | EP | disclosed |
| US-20020156047-A1 | Multi-arm block copolymers as drug delivery vehicles | SHEARWATER CORPORATION | 2002-10-24 | — | — | US | disclosed |
| US-6365146-B1 | POLYAMIDEESTER COPOLYMER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-04-02 | — | — | US | disclosed |
| US-20020035217-A1 | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2002-03-21 | — | — | US | disclosed |
| EP-1176983-A2 | HYPERBRANCHED POLYMERIC MICELLES FOR ENCAPSULATION AND DELIVERY OF HYDROPHOBIC MOLECULES | RUTGERS, THE STATE UNIVERSITY (US) | 2002-02-06 | — | — | EP | disclosed |
| US-6328988-B1 | DRUGS AND COSMETICS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2001-12-11 | — | — | US | disclosed |
| WO-2000065024-A2 | HYPERBRANCHED POLYMERIC MICELLES FOR ENCAPSULATION AND DELIVERY OF HYDROPHOBIC MOLECULES | RUTGERS, THE STATE UNIVERSITY (US) | 2000-11-02 | — | — | WO | disclosed |
| US-4248793-A | REACTING WITH SULFUR TRIOXIDE, NEUTRALIZATION, EXTRACTION, HYDROLYSIS | THE LION FAT & OIL CO., LTD. (JP) | 1981-02-03 | — | — | US | disclosed |
| US-3956222-A | N-SUBSTITUTED ACRYLAMIDE POLYMER | KURARAY CO., LTD. (JA) | 1976-05-11 | — | — | US | disclosed |