Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | ABL1 | P00519 | 5/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | FYN | P06241 | 3/20 | 0.54 |
| ▸ | YES1 | P07947 | 3/20 | 0.54 |
| ▸ | LYN | P07948 | 3/20 | 0.54 |
| ▸ | HCK | P08631 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 3/20 | 0.54 |
| ▸ | BCR | P11274 | 3/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | FGR | P09769 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.54 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676534 | 1.00 | LCK (0.59) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL774454 | 0.88 | LCK (0.61) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL772915 | 0.81 | LCK (0.74) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL14569092 | 0.79 | LCK (0.70) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL14569074 | 0.79 | LCK (0.75) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL771868 | 0.77 | LCK (0.70) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL1540977 | 0.77 | LCK (0.70) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL15891879 | 0.76 | LCK (0.68) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL19390257 | 0.76 | LCK (0.82) | LCKMAPK14ABL1SRCEGFR | |
| SCHEMBL774203 | 0.75 | LCK (0.67) | LCKMAPK14ABL1SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169038-A4 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | claimed |
| EP-1169038-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-09 | — | — | EP | claimed |
| WO-2000062778-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-10-26 | — | — | WO | claimed |