Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6793694 | 0.96 | HDAC4 (0.50) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL6651313 | 0.95 | HDAC6 (0.47) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL6798232 | 0.91 | HDAC6 (0.48) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL29571861 | 0.88 | HDAC4 (0.60) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL8363221 | 0.84 | HDAC4 (0.46) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL23013776 | 0.80 | HDAC4 (0.48) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL20528841 | 0.77 | HDAC4 (0.54) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL21900054 | 0.77 | HDAC4 (0.55) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL23013566 | 0.77 | HDAC6 (0.49) | HDAC6HDAC4HDAC1HDAC5HDAC7 | |
| SCHEMBL21900051 | 0.76 | HDAC4 (0.53) | HDAC6HDAC4HDAC1HDAC5HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482940-A2 | PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003028729-A2 | PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |