Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897734 | 0.87 | MAPT (0.60) | MAPTMAPK14MEN1KMT2ARAB9A | |
| SCHEMBL1455699 | 0.86 | MEN1 (0.58) | MAPTMAPK14MEN1KMT2ARAB9A | |
| SCHEMBL1455951 | 0.84 | MAPT (0.63) | MAPTMCL1MEN1KMT2ARAB9A | |
| SCHEMBL1454593 | 0.82 | MEN1 (0.72) | MAPTMCL1MEN1KMT2ARAB9A | |
| SCHEMBL1454748 | 0.82 | MAPT (0.63) | MAPTMCL1MEN1KMT2ARAB9A | |
| SCHEMBL1454512 | 0.81 | MAPT (0.59) | MAPTMCL1MEN1KMT2ARAB9A | |
| SCHEMBL6787077 | 0.81 | MEN1 (0.75) | MAPTMEN1KMT2ARAB9ALMNA | |
| SCHEMBL6681161 | 0.81 | MAPK14 (0.61) | MAPTMAPK14RAB9AHTTSMN1; SMN2 | |
| SCHEMBL811365 | 0.80 | MAPT (0.60) | MAPTMCL1MEN1KMT2ARAB9A | |
| SCHEMBL6813549 | 0.80 | MEN1 (0.70) | MAPTMCL1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188389-C | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2005-02-09 | — | — | CN | disclosed |
| EP-1077930-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| US-6465455-B1 | TUMOUR NECROSIS FACTOR AND INTERLEUKIN FAMILY INHIBITORS; INHIBITION OF ENZYME P38 KINASE; INFLAMMATION, IMMUNO-REGULATION, ALLERGIES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |
| CN-1359371-A | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2002-07-17 | — | — | CN | disclosed |
| EP-1077930-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059960-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |