SCHEMBL6677197

SCHEMBL6677197

CN1CCC(Oc2cc(NS(=O)(=O)c3ccc4c(c3)CCCC4)ccc2C(F)(F)F)C1

nearest known ligand 0.63

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 16/20 0.63
BRD1 O95696 2/20 0.48
BRPF1 P55201 2/20 0.48
LMNA P02545 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
TRIM24 O15164 1/20 0.48
ALDH1A1 P00352 1/20 0.48
PKM P14618 1/20 0.48
ALOX12 P18054 1/20 0.48
HTT P42858 1/20 0.48
DPP4 P27487 1/20 0.47
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6677188 1.00 UTS2R (0.63) UTS2RBRD1BRPF1LMNASMN1; SMN2
SCHEMBL6686223 0.98 UTS2R (0.63) UTS2RBRD1BRPF1LMNASMN1; SMN2
SCHEMBL6814887 0.88 UTS2R (0.66) UTS2R
SCHEMBL6824191 0.87 UTS2R (0.67) UTS2R
SCHEMBL6819749 0.87 UTS2R (0.67) UTS2R
SCHEMBL5834906 0.86 UTS2R (0.71) UTS2R
SCHEMBL5834910 0.86 UTS2R (0.71) UTS2R
SCHEMBL8339345 0.86 UTS2R (0.66) UTS2RLMNASMN1; SMN2ALDH1A1HTT
SCHEMBL6683280 0.86 UTS2R (0.55) UTS2RSMN1; SMN2PKM
SCHEMBL8337453 0.86 UTS2R (0.55) UTS2RSMN1; SMN2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043369-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043369-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed