Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678240 | 0.86 | SLC6A2 (0.45) | NPC1RAB9AKIF11EPHX2TRPV1 | |
| SCHEMBL6496056 | 0.81 | MAPKAPK2 (0.66) | NPC1RAB9ALMNAHIF1AEPAS1 | |
| SCHEMBL6490755 | 0.80 | CA1 (0.51) | LMNAHIF1AEPAS1 | |
| SCHEMBL6492770 | 0.79 | SLC6A2 (0.52) | KIF11PTGS1LMNASLC6A2 | |
| SCHEMBL6489466 | 0.79 | SLC6A2 (0.52) | KIF11PTGS1LMNASLC6A2 | |
| SCHEMBL6488184 | 0.79 | SLC6A2 (0.52) | KIF11PTGS1LMNASLC6A2 | |
| SCHEMBL6489462 | 0.79 | SLC6A2 (0.52) | KIF11PTGS1LMNASLC6A2 | |
| SCHEMBL6487719 | 0.79 | MELK (0.51) | TRPV1 | |
| SCHEMBL6488729 | 0.79 | TRPV1 (0.51) | TRPV1 | |
| SCHEMBL3914850 | 0.78 | DHODH (0.64) | NPC1RAB9ADHODHEPHX2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |