Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 3/20 | 0.39 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.39 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.38 |
| ▸ | AMDHD2 | Q9Y303 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769616 | 0.87 | MAPK1 (0.55) | MAPK1NOD2ALDH1A1THRBTLR4 | |
| SCHEMBL61395 | 0.83 | MAPK1 (0.75) | MAPK1NOD2ALDH1A1THRBLGALS3 | |
| SCHEMBL31076211 | 0.82 | MAPK1 (0.62) | MAPK1NOD2ALDH1A1THRBLGALS3 | |
| SCHEMBL31076331 | 0.82 | MAPK1 (0.62) | MAPK1NOD2ALDH1A1THRBLGALS3 | |
| SCHEMBL16644661 | 0.82 | MAPK1 (0.52) | MAPK1ALDH1A1THRBTLR4LY96 | |
| SCHEMBL21985823 | 0.82 | MAPK1 (0.52) | MAPK1ALDH1A1THRBTLR4LY96 | |
| SCHEMBL16640643 | 0.82 | MAPK1 (0.52) | MAPK1ALDH1A1THRBTLR4LY96 | |
| SCHEMBL22053386 | 0.82 | MAPK1 (0.52) | MAPK1ALDH1A1THRBTLR4LY96 | |
| SCHEMBL22204677 | 0.75 | MAPK1 (0.44) | MAPK1ALDH1A1THRBTLR4LY96 | |
| SCHEMBL16640655 | 0.73 | MAPK1 (0.51) | MAPK1NOD2ALDH1A1THRBLGALS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171631-B1 | ASSAY FOR DETECTING PHOSPHO-N-ACETYLMURAMYL-PENTAPEPTIDE TRANSLOCASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| US-6537770-B1 | Assay for detecting phospho-N-acetylmuramyl-pentapeptide translocase activity | ASTRAZENECA AB (SE) | 2003-03-25 | — | — | US | disclosed |
| EP-1292701-A1 | ASSAY FOR DETECTION OF TRANSFERASE ENZYME ACTIVITY IN DRUG SCREENING | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| EP-1292702-A1 | ASSAY FOR DETECTION OF TRANSLOCASE ENZYME ACTIVITY IN DRUG SCREENING | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| EP-1171631-A1 | ASSAY FOR DETECTING PHOSPHO-N-ACETYLMURAMYL-PENTAPEPTIDE TRANSLOCASE ACTIVITY | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2001094622-A1 | ASSAY FOR DETECTION OF TRANSFERASE ENZYME ACTIVITY IN DRUG SCREENING | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |
| WO-2001094623-A1 | ASSAY FOR DETECTION OF TRANSLOCASE ENZYME ACTIVITY IN DRUG SCREENING | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |
| WO-2000065087-A1 | ASSAY FOR DETECTING PHOSPHO-N-ACETYLMURAMYL-PENTAPEPTIDE TRANSLOCASE ACTIVITY | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |
| WO-2000044335-A2 | URIDYL PEPTIDE ANTIBIOTIC (UPA) DERIVATIVES, THEIR SYNTHESIS AND USE | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-08-03 | — | — | WO | disclosed |