Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.41 |
| ▸ | PDE4A | P27815 | 10/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679918 | 0.97 | PDE4D (0.41) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6679903 | 0.94 | PDE4D (0.46) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6678984 | 0.91 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6682550 | 0.90 | PDE4D (0.41) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6677546 | 0.90 | MEN1 (0.40) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6675734 | 0.90 | PDE4A (0.49) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6676281 | 0.90 | PDE4D (0.41) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6675315 | 0.90 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6675637 | 0.90 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6661723 | 0.89 | TSHR (0.47) | PDE4DPDE4BPDE4APDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435958-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GmbH (DE) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032993-A1 | USE OF PHOSPHORODIESTERASE IV INHIBITORS | MERCK PATENT GMBH (DE) | 2003-04-24 | — | — | WO | disclosed |
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |