Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.48 |
| ▸ | PPARA | Q07869 | 17/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4867119 | 0.94 | PPARG (0.52) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4867150 | 0.94 | PPARG (0.52) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4822377 | 0.92 | PPARG (0.50) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4822370 | 0.92 | PPARG (0.50) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4824934 | 0.91 | PPARG (0.40) | PPARGPPARA | |
| Arginine SCHEMBL4824931 | 0.91 | PPARG (0.40) | PPARGPPARA | |
| SCHEMBL1860065 | 0.89 | PPARG (0.59) | PPARGPPARAPPARDCACNA1B | |
| SCHEMBL4867157 | 0.86 | PPARG (0.45) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4826319 | 0.85 | PPARG (0.44) | PPARGPPARAPPARDCACNA1B | |
| Arginine SCHEMBL4826312 | 0.85 | PPARG (0.44) | PPARGPPARAPPARDCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436268-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Reddy's Laboratories Ltd. (IN) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033481-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-04-24 | — | — | WO | disclosed |