Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 9/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.66 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681884 | 0.91 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6681475 | 0.91 | HDAC3 (0.69) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6682258 | 0.89 | HDAC1 (0.82) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6683465 | 0.89 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6684025 | 0.88 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6681585 | 0.88 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6682253 | 0.87 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6684746 | 0.85 | HDAC3 (0.77) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6683034 | 0.85 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6817621 | 0.84 | HDAC3 (0.75) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004067480-A2 | SUBSTITUTED PHENYLUREA DERIVATIVES AS HDAC INHIBITORS | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-08-12 | — | — | WO | disclosed |