Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 2/20 | 0.45 |
| ▸ | TGM2 | P21980 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.39 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683982 | 1.00 | IDO1 (0.45) | IDO1TDO2TGM2PDGFRBLRRK2 | |
| SCHEMBL4993255 | 0.91 | PDGFRB (0.49) | IDO1TDO2TGM2PDGFRBLRRK2 | |
| SCHEMBL4993258 | 0.91 | PDGFRB (0.49) | IDO1TDO2TGM2PDGFRBLRRK2 | |
| SCHEMBL5011975 | 0.88 | IDO1 (0.56) | IDO1TDO2TGM2PDGFRBLRRK2 | |
| SCHEMBL5011977 | 0.88 | IDO1 (0.56) | IDO1TDO2TGM2PDGFRBLRRK2 | |
| SCHEMBL4994415 | 0.79 | CDK2 (0.47) | NTRK1AHR | |
| SCHEMBL4994417 | 0.79 | CDK2 (0.47) | NTRK1AHR | |
| SCHEMBL4988836 | 0.78 | MAPT (0.45) | IDO1TGM2PDGFRBLRRK2NTRK1 | |
| SCHEMBL4988837 | 0.78 | MAPT (0.45) | IDO1TGM2PDGFRBLRRK2NTRK1 | |
| SCHEMBL4987869 | 0.77 | IDO1 (0.56) | IDO1TDO2TGM2PDGFRBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |