Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.65 |
| ▸ | LMNA | P02545 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | SERPINA6 | P08185 | 6/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.65 |
| ▸ | SHBG | P04278 | 4/20 | 0.65 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.65 |
| ▸ | PGR | P06401 | 3/20 | 0.65 |
| ▸ | AR | P10275 | 3/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL2042107 | 0.98 | CYP3A4 (0.65) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL4747200 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL1457788 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL3661927 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL3509140 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL25333984 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL571703 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL8069 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL2724646 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 | |
| SCHEMBL5436459 | 0.98 | CYP3A4 (0.67) | CYP3A4LMNASMN1; SMN2ALDH1A1SERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004064720-A2 | A PROCESS TO APPLY THE EFFECTIVENESS OF COCONUT FLOWER | SMT. SULOCHANADEVI SINGHANIA SCHOOL (IN) | 2004-08-05 | — | — | WO | claimed |