Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.82 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.82 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.82 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.82 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6655015 | 0.90 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7196766 | 0.90 | MAPK14 (0.79) | MAPK14MAPK13MAPK12MAPK11KCNMA1 | |
| SCHEMBL7198829 | 0.90 | MAPK14 (0.79) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7193764 | 0.88 | MAPK13 (0.76) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL7196663 | 0.87 | MAPK13 (0.74) | MAPK14MAPK13MAPK12MAPK11KCNMA1 | |
| SCHEMBL7196772 | 0.85 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7210815 | 0.85 | MAPK13 (0.62) | MAPK14MAPK13MAPK12MAPK11KCNMA1 | |
| SCHEMBL7198680 | 0.83 | MAPK13 (0.78) | MAPK14MAPK13MAPK12MAPK11KCNMA1 | |
| SCHEMBL6655830 | 0.82 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7207479 | 0.82 | MAPK13 (0.76) | MAPK14MAPK13MAPK12MAPK11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966424-B1 | AMINOBENZOPHENONES AS INHIBITORS OF INTERLEUKIN AND TNF | LEO PHARMA AS (DK) | 2004-06-23 | — | — | EP | disclosed |
| US-6313174-B1 | FOR THERAPY AND PROPHYLAXIS OF ASTHMA, ALLERGY, RHEUMATOID ARTHRITIS, SPONDYLOARTHRITIS, GOUT, ATHEROSCLEROSIS, CHRONIC INFLAMMATORY BOWEL DISEASE, PROLIFERATIVE AND INFLAMMATORY SKIN DISORDERS | Leo Pharmaceutical Products Ltd.A/S/ (Løvens kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-11-06 | — | — | US | disclosed |