Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 11/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640170 | 1.00 | HTR2C (0.51) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL6640174 | 1.00 | HTR2C (0.51) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| Hydrochloric Acid SCHEMBL6647341 | 0.79 | HTR2C (0.53) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| Hydrochloric Acid SCHEMBL6647520 | 0.79 | HTR2C (0.55) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL6641609 | 0.78 | HTR2C (0.79) | HTR2CHTR6MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL6643620 | 0.77 | HTR2C (0.53) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL5239100 | 0.77 | HTR2C (0.63) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| Fumaric Acid SCHEMBL6642673 | 0.77 | HTR2C (0.66) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| Fumaric Acid SCHEMBL6642671 | 0.77 | HTR2C (0.66) | HTR2CHTR6MTNR1AMTNR1BKDM4E | |
| SCHEMBL5238069 | 0.77 | HTR2C (0.51) | HTR2CHTR6MTNR1AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109813-B1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RES LTD (GB) | 2004-08-11 | — | — | EP | disclosed |
| US-6433175-B1 | ANTISEROTONINE AGENTS | VERNALIS RESEARCH LIMITED (GB) | 2002-08-13 | — | — | US | disclosed |