Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.66 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699329 | 0.84 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6688261 | 0.84 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL6683041 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6681005 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6682256 | 0.81 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586085 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699341 | 0.78 | PDE4D (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4701819 | 0.77 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699816 | 0.76 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699913 | 0.76 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004056798-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2004-07-08 | — | — | WO | claimed |
| WO-2004056798-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2004-07-08 | — | — | WO | disclosed |