SCHEMBL6686201

SCHEMBL6686201

CCC(CC)COc1ccc(CN2CCCC2C(N)=O)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 1/20 0.51
MAOA P21397 3/20 0.48
MAOB P27338 3/20 0.48
CD274 Q9NZQ7 6/20 0.47
SCN3A Q9NY46 1/20 0.47
KDM4E B2RXH2 1/20 0.47
OPRM1 P35372 2/20 0.46
OPRD1 P41143 2/20 0.46
OPRK1 P41145 2/20 0.46
NPSR1 Q6W5P4 1/20 0.46
PPARD Q03181 1/20 0.44
PDCD1 Q15116 1/20 0.41
GRM2 Q14416 1/20 0.41
EGFR P00533 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6690365 1.00 SPHK1 (0.51) SPHK1MAOAMAOBCD274SCN3A
SCHEMBL6169023 0.78 SCN3A (0.75) SPHK1MAOAMAOBCD274SCN3A
SCHEMBL6169037 0.78 SCN3A (0.75) SPHK1MAOAMAOBCD274SCN3A
SCHEMBL4844700 0.74 SPHK1 (0.59) SPHK1MAOAMAOBCD274SCN3A
SCHEMBL6170788 0.74 MAOB (0.72) SPHK1MAOAMAOBSCN3A
SCHEMBL6170791 0.74 MAOB (0.72) SPHK1MAOAMAOBSCN3A
SCHEMBL7309417 0.71 SPHK1 (0.63) SPHK1MAOAMAOBCD274SCN3A
SCHEMBL9151576 0.70 MAOB (0.64) SPHK1MAOAMAOBCD274SCN3A
SCHEMBL9147565 0.70 MAOB (0.64) SPHK1MAOAMAOBCD274SCN3A
SCHEMBL408684 0.70 SPHK1 (0.71) SPHK1MAOAMAOBCD274SCN3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004087125-A1 AMINO ACID DERIVATIVES AS INHIBITORS OF MAMMALIAN SODIUM CHANNELS IONIX PHARMACEUTICALS LIMITED (GB) 2004-10-14 WO disclosed