Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5657625 | 0.92 | TRPV1 (0.68) | TRPV1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5659169 | 0.88 | TRPV1 (0.68) | TRPV1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5658216 | 0.87 | TRPV1 (0.72) | TRPV1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5656769 | 0.82 | TRPV1 (0.70) | TRPV1KDM4EGSK3B | |
| SCHEMBL4025617 | 0.81 | TRPV1 (0.72) | TRPV1 | |
| SCHEMBL4019256 | 0.80 | TRPV1 (0.56) | TRPV1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5658533 | 0.80 | TRPV1 (0.62) | TRPV1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5656245 | 0.80 | TRPV1 (0.73) | TRPV1KDM4EGSK3B | |
| SCHEMBL4025640 | 0.79 | TRPV1 (0.84) | TRPV1 | |
| SCHEMBL5660751 | 0.79 | TRPV1 (0.72) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490340-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080578-A1 | HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |