Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365659 | 0.84 | CYP3A4 (0.36) | POLBLMNACYP3A4HTTSMN1; SMN2 | |
| SCHEMBL5970244 | 0.81 | CETP (0.33) | POLBCYP3A4HTTSMN1; SMN2PRSS1 | |
| SCHEMBL1929736 | 0.80 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2KLK7 | |
| SCHEMBL1295811 | 0.80 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2KLK7 | |
| SCHEMBL5970585 | 0.80 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2KLK7 | |
| SCHEMBL5970972 | 0.79 | KMT2A (0.42) | LMNATSHRPRSS1CTSGCTRB1 | |
| SCHEMBL13094532 | 0.79 | KLK7 (0.36) | LMNACYP3A4HTTSMN1; SMN2TSHR | |
| SCHEMBL16147725 | 0.79 | KLK7 (0.36) | LMNACYP3A4HTTSMN1; SMN2TSHR | |
| SCHEMBL13094538 | 0.77 | ASAH1 (0.40) | — | |
| SCHEMBL13094535 | 0.77 | ASAH1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004072047-A1 | INDOLES, BENZIMIDAZOLES OR NAPHHIMIDAZOLES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-26 | — | — | WO | disclosed |