SCHEMBL6686872

SCHEMBL6686872

C[C@H](N)C#Cc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2s1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERBB2 P04626 18/20 0.58
EGFR P00533 13/20 0.56
ERBB4 Q15303 3/20 0.55
MEN1 O00255 1/20 0.55
RGS12 O14924 1/20 0.55
GMNN O75496 1/20 0.55
ALDH1A1 P00352 1/20 0.55
LMNA P02545 1/20 0.55
RAF1 P04049 1/20 0.55
TP53 P04637 1/20 0.55
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
MAPT P10636 1/20 0.55
CYP2C9 P11712 1/20 0.55
HPGD P15428 1/20 0.55
ALOX15 P16050 1/20 0.55
NFKB1 P19838 1/20 0.55
APEX1 P27695 1/20 0.55
MAPK1 P28482 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6495819 1.00 ERBB2 (0.58) ERBB2EGFRERBB4MEN1RGS12
SCHEMBL6483050 1.00 ERBB2 (0.58) ERBB2EGFRERBB4MEN1RGS12
SCHEMBL6493599 0.91 ERBB2 (0.58) ERBB2EGFR
SCHEMBL6493597 0.91 ERBB2 (0.58) ERBB2EGFR
SCHEMBL6493384 0.89 ERBB2 (0.49) ERBB2EGFRERBB4MEN1RGS12
SCHEMBL6493385 0.89 ERBB2 (0.49) ERBB2EGFRERBB4MEN1RGS12
SCHEMBL6483748 0.88 ERBB2 (0.59) ERBB2EGFRERBB4MEN1RGS12
SCHEMBL6826933 0.87 ERBB2 (0.65) ERBB2EGFRERBB4MEN1RGS12
Hydrochloric Acid SCHEMBL6826943 0.86 ERBB2 (0.64) ERBB2EGFRERBB4MEN1RGS12
Hydrochloric Acid SCHEMBL6491833 0.86 ERBB2 (0.57) ERBB2EGFRERBB4MEN1RGS12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1463507-A1 THIENOPYRIMIDINE COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS SmithKline Beecham Corporation (US) 2004-10-06 EP disclosed
WO-2003053446-A1 THIENOPYRIMIDINE COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-07-03 WO disclosed