Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | IDE | P14735 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14158232 | 0.81 | NPC1 (0.43) | NPC1KDM4ESLC16A3SMN1; SMN2EGFR | |
| SCHEMBL14699371 | 0.80 | NPC1 (0.54) | NPC1 | |
| SCHEMBL29921411 | 0.80 | NPC1 (0.37) | NPC1PADI4SLC16A3EGFRIGF1R | |
| SCHEMBL28381362 | 0.78 | NPC1 (0.42) | NPC1KDM4ESMN1; SMN2EGFRIGF1R | |
| SCHEMBL14158477 | 0.77 | PDE5A (0.40) | NPC1KDM4ESLC16A3SMN1; SMN2EGFR | |
| SCHEMBL23908827 | 0.77 | NPC1 (0.43) | NPC1KDM4ESLC16A3SMN1; SMN2EGFR | |
| SCHEMBL23908911 | 0.76 | MAPT (0.45) | NPC1SLC16A3TSHRHSD17B10AKR1B1 | |
| SCHEMBL30142294 | 0.76 | NPC1 (0.47) | NPC1SMN1; SMN2TSHRHPGDKMT2A | |
| SCHEMBL30142296 | 0.76 | NPC1 (0.47) | NPC1SMN1; SMN2TSHRHPGDKMT2A | |
| SCHEMBL4109728 | 0.76 | NPC1 (0.45) | NPC1KDM4ESMN1; SMN2EGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487804-A2 | AMINOINDAZOLE DERIVATIVES AS PROTEIN-KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078403-A2 | DERIVES D’AMINOINDAZOLES COMME INHIBITEURS DE PROTEINE-KINASE | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |