Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.62 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884312 | 0.93 | GRIA1 (0.69) | GRIA1GRIA3PDE4DNPC1MAPT | |
| SCHEMBL1882837 | 0.87 | GRIA1 (0.59) | GRIA1GRIA3PDE4DGRM5BRD4 | |
| SCHEMBL1882156 | 0.84 | GRIA1 (0.69) | GRIA1GRIA3PDE4DMAPTMAPK1 | |
| SCHEMBL1887704 | 0.81 | GRIA1 (0.71) | GRIA1GRIA3PDE4DMAPK1GRM5 | |
| SCHEMBL1884427 | 0.81 | GRIA1 (0.68) | GRIA1GRIA3PDE4DDHODHGRM5 | |
| SCHEMBL1884948 | 0.80 | GRIA1 (0.70) | GRIA1GRIA3PDE4DMAPTGRM5 | |
| SCHEMBL1883270 | 0.80 | GRIA1 (0.67) | GRIA1GRIA3PDE4DGRM5BRD4 | |
| SCHEMBL1884216 | 0.79 | GRIA1 (0.69) | GRIA1GRIA3PDE4DMAPK1GRM5 | |
| SCHEMBL1883158 | 0.79 | GRIA1 (0.69) | GRIA1GRIA3PDE4DGRM5BRD4 | |
| SCHEMBL1881040 | 0.79 | GRIA1 (0.69) | GRIA1GRIA3PDE4DMAPK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |