Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 12/20 | 0.81 |
| ▸ | PDE4A | P27815 | 9/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.74 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693227 | 0.92 | TNF (0.82) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6690004 | 0.90 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6691297 | 0.90 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3121844 | 0.90 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6692796 | 0.86 | TNF (0.80) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6098481 | 0.85 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3120500 | 0.85 | PDE4A (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15015430 | 0.84 | TNF (0.68) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2988010 | 0.84 | TNF (0.69) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6692793 | 0.83 | PDE4A (0.89) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477486-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2004-11-17 | — | — | EP | claimed |
| EP-1477486-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2004-11-17 | — | — | EP | disclosed |
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| EP-1004572-A2 | Amines as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004580-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-1004581-A2 | Process for the preparation of thalidomide | CELGENE CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5877200-A | Cyclic amides | CELGENE CORPORATION (US) | 1999-03-02 | — | — | US | disclosed |
| US-5698579-A | INHIBITOR OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |
| US-5605914-A | INHIBITORS OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| EP-0706521-A1 | NOVEL IMIDES | CELGENE CORPORATION (US) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001348-A2 | IMIDES AS INHIBITORS OF TNP ALPHA | CELGENE CORPORATION (US) | 1995-01-12 | — | — | WO | disclosed |