Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.68 |
| ▸ | PDE6C | P51160 | 3/20 | 0.56 |
| ▸ | PDE6D | O43924 | 2/20 | 0.56 |
| ▸ | PDE6A | P16499 | 2/20 | 0.56 |
| ▸ | PDE6G | P18545 | 2/20 | 0.56 |
| ▸ | PDE6B | P35913 | 2/20 | 0.56 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695047 | 0.91 | PDE5A (0.70) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7164989 | 0.89 | PDE5A (0.68) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7168262 | 0.86 | PDE5A (0.63) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7163190 | 0.86 | PDE5A (0.63) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5537736 | 0.84 | PDE5A (0.72) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5014248 | 0.84 | PDE5A (0.72) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL6689536 | 0.84 | PDE5A (0.72) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL6697475 | 0.84 | PDE5A (0.85) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5595642 | 0.84 | PDE5A (0.76) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL7171984 | 0.83 | PDE5A (0.72) | PDE5APDE6CPDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004527459-A | — | — | 2004-09-09 | — | — | JP | claimed |
| US-20030225128-A1 | Quinoline inhibitors of cGMP phosphodiesterase | BI YINGZHI (US) | 2003-12-04 | — | — | US | claimed |
| US-20020177587-A1 | Quinoline inhibitors of cGMP phosphodiesterase | BRISTOL-MYERS SQUIBB COMPANY | 2002-11-28 | — | — | US | claimed |
| WO-2002020489-A2 | QUINOLINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225128-A1 | Quinoline inhibitors of cGMP phosphodiesterase | PDE5A, PDE3A, PDE2A | PDE5A 1/4885PDE6C 19/4885PDE6D 24/4885 |
| US-20020177587-A1 | Quinoline inhibitors of cGMP phosphodiesterase | PDE5A, PDE2A, PDE3A | PDE5A 1/4885PDE6C 19/4885PDE6D 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.