Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclosporine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA known ✓ | P62937 | 5/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 13/20 | 1.00 |
| ▸ | PPP3CA | Q08209 | 3/20 | 1.00 |
| ▸ | FKBP1B | P68106 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | RARB | P10826 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CYP3A5 | P20815 | 1/20 | 1.00 |
| ▸ | TACR2 | P21452 | 1/20 | 1.00 |
| ▸ | PPIB | P23284 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclosporine SCHEMBL21170318 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| SCHEMBL23382247 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239446 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24224445 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL25083206 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239035 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL23192320 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| SCHEMBL23110210 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL24239036 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 | |
| Cyclosporine SCHEMBL23192319 | 1.00 | ABCB1 (1.00) | ABCB1PPIAPPP3CAFKBP1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329415-B2 | Lysis reagent for use with capture-in-solution immunoassay | ABBOTT LABORATORIES (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120288875-A1 | Diagnostic Test For The Detection Of A Molecule Or Drug In Whole Blood | ABBOTT LABORATORIES (US) | 2012-11-15 | — | — | US | disclosed |
| US-8221986-B2 | Diagnostic test for the detection of a molecule or drug in whole blood | ABBOTT LABORATORIES (US) | 2012-07-17 | — | — | US | disclosed |
| US-8221986-B2 | Diagnostic test for the detection of a molecule or drug in whole blood | ABBOTT LABORATORIES (US) | 2012-07-17 | — | — | US | disclosed |
| US-8129127-B2 | Assay for immunosuppressant drugs | ABBOTT LABORATORIES (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129127-B2 | Assay for immunosuppressant drugs | ABBOTT LABORATORIES (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110171662-A1 | NON-DENATURING LYSIS REAGENT | ABBOTT LABORATORIES (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110091997-A1 | IMMUNOSUPPRESSANT DRUG EXTRACTION REAGENT FOR IMMUNOASSAYS | ABBOTT LABORATORIES (US) | 2011-04-21 | — | — | US | disclosed |
| US-7914999-B2 | Identifying immunosuppressant drugs in blood via cell rupture without protein denaturation | ABBOTT LABORATORIES (US) | 2011-03-29 | — | — | US | disclosed |
| US-7914999-B2 | Identifying immunosuppressant drugs in blood via cell rupture without protein denaturation | ABBOTT LABORATORIES (US) | 2011-03-29 | — | — | US | disclosed |
| US-7883855-B2 | extracting sirolimus or everolimus from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components; reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water; kits | ABBOTT LABORATORIES (US) | 2011-02-08 | — | — | US | disclosed |
| US-20090325193-A1 | Diagnostic Test For The Detection Of A Molecule Or Drug In Whole Blood | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090325197-A1 | ASSAY FOR IMMUNOSUPPRESSANT DRUGS | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090325193-A1 | Diagnostic Test For The Detection Of A Molecule Or Drug In Whole Blood | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-20090325197-A1 | ASSAY FOR IMMUNOSUPPRESSANT DRUGS | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-20080160499-A1 | NON-DENATURING LYSIS REAGENT | ABBOTT LABORATORIES | 2008-07-03 | — | — | US | disclosed |
| US-20080160499-A1 | NON-DENATURING LYSIS REAGENT | ABBOTT LABORATORIES | 2008-07-03 | — | — | US | disclosed |
| US-20080020401-A1 | Immunosuppressant drug extraction reagent for immunoassays | BARCLAYS BANK PLC | 2008-01-24 | — | — | US | disclosed |