Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26483 | 0.87 | TSHR (1.00) | TSHRPPARDTP53TDP1ACHE | |
| SCHEMBL5961215 | 0.87 | TSHR (1.00) | TSHRPPARDTP53TDP1ACHE | |
| SCHEMBL28492909 | 0.84 | TSHR (0.94) | TSHRPPARDTP53TDP1ACHE | |
| Ammonia Solution, Strong SCHEMBL27738152 | 0.84 | TSHR (0.94) | TSHRPPARDTP53TDP1ACHE | |
| SCHEMBL31574613 | 0.84 | TSHR (0.94) | TSHRPPARDTP53TDP1ACHE | |
| SCHEMBL11745101 | 0.84 | TSHR (0.94) | TSHRPPARDTP53TDP1ACHE | |
| SCHEMBL29034374 | 0.84 | TSHR (0.94) | TSHRPPARDTP53TDP1ACHE | |
| SCHEMBL25093119 | 0.81 | TSHR (0.48) | TSHRPPARDTP53TDP1ACHE | |
| SCHEMBL30529809 | 0.77 | TSHR (0.79) | TSHRPPARDTP53TDP1ACHE | |
| Trimethylammonium SCHEMBL27645329 | 0.77 | TSHR (0.79) | TSHRPPARDTP53TDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004085448-A2 | UNSATURATED PHOSPHINYL-PHOSPHONATE PHOSPHATE TRANSPORT INHIBITORS | GENZYME CORPORATION (US) | 2004-10-07 | — | — | WO | disclosed |
| US-5574024-A | Methylene phosphonoalkylphosphinates, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism | EBETINO FRANK H (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0298553-B1 | METHYLENE PHOSPHONOALKYLPHOSPHINATES, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | Norwich Eaton Pharmaceuticals, Inc. (US) | 1992-01-15 | — | — | EP | disclosed |
| EP-0298553-A1 | Methylene phosphonoalkylphosphinates, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-01-11 | — | — | EP | disclosed |