Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.43 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641651 | 0.90 | BTK (0.50) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5818332 | 0.86 | BTK (0.48) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6690528 | 0.85 | BTK (0.49) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5803835 | 0.84 | BTK (0.50) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6693408 | 0.83 | BTK (0.56) | BTKLCKEGFR | |
| SCHEMBL5817781 | 0.82 | BTK (0.54) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6667380 | 0.80 | BTK (0.66) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5823682 | 0.80 | BTK (0.59) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6638074 | 0.80 | BTK (0.46) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL6685312 | 0.80 | BTK (0.56) | BTKLCKLYNNUDT14NUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |