Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 5/20 | 0.48 |
| ▸ | CDC25B | P30305 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | VDR | P11473 | 1/20 | 0.43 |
| ▸ | DHCR24 | Q15392 | 4/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502677 | 1.00 | CDC25A (0.48) | CDC25ACDC25BUSP2VDRDHCR24 | |
| SCHEMBL13853984 | 0.87 | CDC25A (0.50) | CDC25ACDC25BUSP2VDRDHCR24 | |
| SCHEMBL6830893 | 0.87 | CDC25A (0.50) | CDC25ACDC25BUSP2VDRDHCR24 | |
| SCHEMBL4180944 | 0.87 | CDC25A (0.50) | CDC25ACDC25BUSP2VDRDHCR24 | |
| SCHEMBL13392661 | 0.87 | CDC25A (0.50) | CDC25ACDC25BUSP2VDRDHCR24 | |
| SCHEMBL16587978 | 0.85 | CDC25A (0.44) | CDC25ACDC25BUSP2VDRNR1H4 | |
| SCHEMBL2609727 | 0.85 | CDC25A (0.59) | CDC25ACDC25BNR1H4GPBAR1AKR1B10 | |
| SCHEMBL9883783 | 0.85 | CDC25A (0.44) | CDC25ACDC25BUSP2VDRNR1H4 | |
| SCHEMBL9010567 | 0.85 | CDC25A (0.59) | CDC25ACDC25BNR1H4GPBAR1AKR1B10 | |
| SCHEMBL9883785 | 0.85 | CDC25A (0.59) | CDC25ACDC25BNR1H4GPBAR1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464640-A2 | 20-Epi-16-ene-25-OH-D3-analogs | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| EP-0808833-B1 | Vitamin D3 analogs | HOFFMANN LA ROCHE (CH) | 2004-09-22 | — | — | EP | disclosed |
| US-6452028-B1 | 20-EPI-16-ENE ANALOGS FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS, SKIN DISEASES AND SEBACEOUS GLAND DISEASES | HOFFMANN-LA ROCHE INC. | 2002-09-17 | — | — | US | disclosed |
| EP-0808833-A2 | Vitamin D3 analogs | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-26 | — | — | EP | disclosed |