Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154688 | 0.95 | ABCB1 (0.42) | GRIN2BABCB1ADAM17MMP2MMP9 | |
| SCHEMBL6690779 | 0.91 | GRIN2B (0.50) | GRIN2BABCB1ADAM17MMP2MMP9 | |
| SCHEMBL6151725 | 0.91 | GRIN2B (0.50) | GRIN2BABCB1ADAM17MMP2MMP9 | |
| SCHEMBL6152148 | 0.91 | GRIN2B (0.50) | GRIN2BABCB1ADAM17MMP2MMP9 | |
| SCHEMBL6698141 | 0.87 | ABCB1 (0.43) | GRIN2BABCB1ADAM17MMP2MMP9 | |
| SCHEMBL6902035 | 0.87 | ABCB1 (0.43) | GRIN2BABCB1ADAM17MMP2MMP9 | |
| SCHEMBL6690805 | 0.85 | GRIN2B (0.44) | GRIN2BABCB1ADAM17MMP2MMP9 | |
| SCHEMBL8857324 | 0.81 | OPRL1 (0.51) | GRIN2BOPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL7331271 | 0.79 | GRIN2B (0.55) | GRIN2BADAM17MMP2MMP9OPRM1 | |
| SCHEMBL9131979 | 0.79 | GRIN2B (0.55) | GRIN2BADAM17MMP2MMP9OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149831-B1 | Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor | PFIZER PROD INC (US) | 2004-09-01 | — | — | EP | disclosed |
| US-20020016466-A1 | Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor | PFIZER INC. | 2002-02-07 | — | — | US | disclosed |
| EP-1149831-A1 | Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor | Pfizer Products Inc. (US) | 2001-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016466-A1 | Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor | CYP4A11, CYP2S1, CYP4B1 | GRIN2B 3961/4885ABCB1 994/4885ADAM17 4279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.