SCHEMBL6691176

SCHEMBL6691176

C[Si](C)(C)c1cnc(CSc2cnc(NC(=O)Nc3c(F)cccc3F)s2)o1

nearest known ligand 0.78

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 20/20 0.78
CCNE2 O96020 19/20 0.78
CCNE1 P24864 19/20 0.78
CDK4 P11802 13/20 0.78
CCND1 P24385 13/20 0.78
CCNB2 O95067 10/20 0.78
CDK1 P06493 10/20 0.78
CCNB1 P14635 10/20 0.78
CCNB3 Q8WWL7 10/20 0.78
CCND2 P30279 1/20 0.50
CCND3 P30281 1/20 0.50
CCNT1 O60563 1/20 0.46
CDK7 P50613 1/20 0.46
CDK9 P50750 1/20 0.46
CCNH P51946 1/20 0.46
MNAT1 P51948 1/20 0.46
CCNA1 P78396 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6694359 0.88 CDK2 (0.78) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL6695938 0.81 CCNE2 (0.76) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL6246897 0.77 CDK2 (0.47) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL6246901 0.77 CDK2 (0.47) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL7678651 0.76 CCNE2 (0.79) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL6692794 0.75 CDK2 (0.63) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL6694369 0.75 CDK2 (0.60) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL6689507 0.74 CDK2 (0.61) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL6695162 0.73 CDK2 (0.77) CDK2CCNE2CCNE1CDK4CCND1
SCHEMBL4731415 0.72 CCNE2 (0.72) CDK2CCNE2CCNE1CDK4CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004113353-A1 SILICON-COMPRISING AMINOTHIAZOLE DERIVATIVES AS CDK INHIBITORS AMEDIS PHARMACEUTICALS LTD. (GB) 2004-12-29 WO claimed
WO-2004113353-A1 SILICON-COMPRISING AMINOTHIAZOLE DERIVATIVES AS CDK INHIBITORS AMEDIS PHARMACEUTICALS LTD. (GB) 2004-12-29 WO disclosed