Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.71 |
| ▸ | TNF | P01375 | 5/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21494489 | 0.95 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL23000612 | 0.95 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL21494487 | 0.95 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6693901 | 0.92 | TNF (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6692793 | 0.88 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL537289 | 0.88 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL537150 | 0.88 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6690298 | 0.88 | TNF (0.83) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL3128437 | 0.87 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL21494520 | 0.86 | TNF (0.87) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477486-A2 | Imides as inhibitors of TNF alpha | CELGENE CORPORATION (US) | 2004-11-17 | — | — | EP | claimed |
| EP-0706521-B1 | IMIDES AS TNF ALPHA INHIBITORS | CELGENE CORP (US) | 2002-10-02 | — | — | EP | claimed |
| WO-2019201255-A1 | ISOINDOLE DERIVATIVE | 天津合美医药科技有限公司 | 2019-10-24 | — | — | WO | disclosed |