SCHEMBL669218

SCHEMBL669218

Nc1cnc(Br)c(Cl)n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29870162 1.00
SCHEMBL18703941 0.81
SCHEMBL30876843 0.81
SCHEMBL8257576 0.77
SCHEMBL16972864 0.77
SCHEMBL30683717 0.75
SCHEMBL273776 0.75
SCHEMBL7065526 0.75
SCHEMBL13954212 0.73
SCHEMBL24538309 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 296 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747255-A1 MODULATORS OF THE ADENOSINE A2A AND A2B RECEPTOR Ryvu Therapeutics S.A. (PL) 2026-05-27 EP disclosed
US-20260125398-A1 5,6-FUSED BICYCLIC ALCOHOL COMPOUNDS AS 15-PROSTAGLANDIN DEHYDROGENASE MODULATORS AMGEN INC. (US) 2026-05-07 US disclosed
EP-4736856-A2 BICYCLIC AMINES AS CDK2 INHIBITORS Incyte Corporation (US) 2026-05-06 EP disclosed
US-20260116881-A1 KIF MODULATOR COMPOUNDS AND METHODS OF USE IAMBIC THERAPEUTICS INC (US) 2026-04-30 US disclosed
US-12583824-B2 6-membered heteroarylaminosulfonamides for treating diseases and conditions mediated by deficient CFTR activity GENZYME CORPORATION (US) 2026-03-24 US disclosed
EP-4709481-A1 5,6-FUSED AND 6,6-FUSED BICYCLIC ALCOHOLS AND ETHERS AND COMPOSITIONS FOR USE AS 15-PROSTAGLANDIN DEHYDROGENASE MODULATORS Amgen Inc. (US) 2026-03-18 EP disclosed
EP-4041731-B1 BICYCLIC AMINES AS CDK2 INHIBITORS INCYTE CORP (US) 2026-02-18 EP disclosed
US-20260022119-A1 BICYCLIC AMINES AS CDK2 INHIBITORS INCYTE CORPORATION 2026-01-22 US disclosed
EP-4126879-B1 N-PHENYL SUBSTITUTED INDOLE DERIVATIVES AS MYT1 INHIBITORS FOR THE TREATMENT OF CANCER REPARE THERAPEUTICS INC (CA) 2026-01-21 EP disclosed
US-12466828-B2 Bicyclic amines as CDK2 inhibitors INCYTE CORPORATION (US) 2025-11-11 US disclosed
EP-1107960-A1 PYRAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 2001-06-20 EP disclosed
US-6083951-A FOR THE TREATMENT OF DISEASES OR MEDICAL CONDITIONS SUCH AS HYPERTENSION, PULMONARY HYPERTENSION, CARDIAC OR CEREBRAL CIRCULATORY DISEASE AND RENAL DISEASE ZENECA LIMITED (GB) 2000-07-04 US disclosed
CN-1253551-A Pyrazine compounds GLAXO GROUP LTD (GB) 2000-05-17 CN disclosed
WO-2000012488-A1 PYRAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 2000-03-09 WO disclosed
EP-0966448-A1 PYRAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 1999-12-29 EP disclosed
EP-0752986-B1 N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ZENECA LTD (GB) 1999-05-19 EP disclosed
US-5861401-A TREATMENT OF CONGESTIVE HEART FAILURE ZENECA LIMITED (GB) 1999-01-19 US disclosed
WO-1998038174-A1 PYRAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 1998-09-03 WO disclosed
EP-0752986-A1 N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ZENECA LIMITED (GB) 1997-01-15 EP disclosed
WO-1995026957-A1 N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS ZENECA LIMITED (GB) 1995-10-12 WO disclosed