Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692699 | 1.00 | LRRK2 (0.49) | LRRK2RAF1AURKADHFRRET | |
| SCHEMBL6690293 | 0.89 | RAF1 (0.47) | LRRK2RAF1AURKADHFRRET | |
| SCHEMBL6690291 | 0.89 | RAF1 (0.47) | LRRK2RAF1AURKADHFRRET | |
| SCHEMBL6687681 | 0.88 | RAF1 (0.62) | LRRK2RAF1AURKADHFRPLK4 | |
| SCHEMBL6687680 | 0.88 | RAF1 (0.62) | LRRK2RAF1AURKADHFRPLK4 | |
| SCHEMBL6697120 | 0.80 | RAF1 (0.54) | LRRK2RAF1DHFRPLK4PLK1 | |
| SCHEMBL6533506 | 0.77 | MAPT (0.46) | RAF1AURKAPLK4PLK1NOX4 | |
| SCHEMBL6533508 | 0.77 | MAPT (0.46) | RAF1AURKAPLK4PLK1NOX4 | |
| SCHEMBL5476173 | 0.74 | RAF1 (0.71) | LRRK2RAF1AURKADHFRRET | |
| SCHEMBL5476171 | 0.74 | RAF1 (0.71) | LRRK2RAF1AURKADHFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069998-A2 | OXINDOLE DERIVATIVES AS ANTIMICROBIAL AGENTS | ARROW THERAPEUTICS LIMITED (GB) | 2004-08-19 | — | — | WO | disclosed |