Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 8/20 | 0.39 |
| ▸ | HTR2B | P41595 | 8/20 | 0.39 |
| ▸ | HTR2A | P28223 | 6/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489804 | 0.88 | EIF2AK3 (0.48) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 | |
| SCHEMBL6500088 | 0.88 | EIF2AK3 (0.50) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 | |
| SCHEMBL6492599 | 0.88 | HTR2A (0.51) | EIF2AK3HTR2CHTR2BHTR2ARIPK1 | |
| SCHEMBL6500118 | 0.86 | HTR2C (0.49) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 | |
| SCHEMBL6491014 | 0.86 | EIF2AK3 (0.50) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 | |
| SCHEMBL6692999 | 0.86 | EIF2AK3 (0.45) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 | |
| SCHEMBL6489031 | 0.86 | HTR2A (0.51) | EIF2AK3HTR2CHTR2BHTR2ARIPK1 | |
| SCHEMBL6490743 | 0.86 | EIF2AK3 (0.49) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 | |
| SCHEMBL6498678 | 0.86 | EIF2AK3 (0.49) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 | |
| SCHEMBL6490739 | 0.86 | EIF2AK3 (0.49) | EIF2AK3HTR2CHTR2BHTR2ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |