Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 3/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | CMA1 | P23946 | 7/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693361 | 1.00 | KLK5 (0.54) | KLK5ACEDPP4F2PRSS1 | |
| SCHEMBL6692626 | 0.85 | KLK5 (0.56) | KLK5ACEF2PRSS1CMA1 | |
| SCHEMBL6692625 | 0.85 | KLK5 (0.56) | KLK5ACEF2PRSS1CMA1 | |
| SCHEMBL6692019 | 0.84 | DPP4 (0.53) | KLK5DPP4 | |
| SCHEMBL6692023 | 0.84 | DPP4 (0.53) | KLK5DPP4 | |
| SCHEMBL5916350 | 0.79 | ACE (0.72) | KLK5ACECMA1 | |
| SCHEMBL5916353 | 0.77 | KLK5 (0.78) | KLK5ACEF2PRSS1CMA1 | |
| SCHEMBL6686979 | 0.76 | ATM (0.50) | KLK5ACE | |
| SCHEMBL3711127 | 0.76 | ACE (0.67) | KLK5ACECMA1 | |
| SCHEMBL3711125 | 0.76 | ACE (0.67) | KLK5ACECMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089362-A1 | 2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS | NOVO NORDISK A/S (DK) | 2004-10-21 | — | — | WO | disclosed |