Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789108 | 0.81 | MAPK14 (0.57) | MAPK14ADORA2AADORA1CSNK1DCSNK1E | |
| SCHEMBL5849136 | 0.78 | ADORA1 (0.45) | MAPK14ADORA1ALDH1A1NPC1RAB9A | |
| SCHEMBL4826188 | 0.78 | MAPK9 (0.56) | MAPK14ADORA1CSNK1DKDM1AMAPK13 | |
| SCHEMBL6937232 | 0.76 | MAPK9 (0.44) | MAPK14ADORA2AADORA1ALDH1A1CSNK1D | |
| SCHEMBL5787744 | 0.75 | CSNK1D (0.55) | MAPK14CSNK1DCSNK1ENPC1RAB9A | |
| SCHEMBL5847952 | 0.74 | MAPK9 (0.43) | MAPK14ALDH1A1CSNK1DNPC1RAB9A | |
| SCHEMBL5788934 | 0.74 | GRIN1 (0.45) | MAPK14CSNK1DNPC1RAB9AMAPT | |
| SCHEMBL6936520 | 0.74 | GSK3B (0.58) | MAPK14ADORA2AADORA1ALDH1A1CSNK1D | |
| SCHEMBL6936522 | 0.74 | GSK3B (0.35) | MAPK14ADORA2AADORA1CSNK1DCSNK1E | |
| Hydrochloric Acid SCHEMBL6935269 | 0.73 | GRIN1 (0.45) | MAPK14CSNK1DNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448564-A2 | SUBSTITUTED INDOLIZINE-LIKE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003044021-A2 | SUBSTITUTED INDOLIZINE-LIKE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2003-05-30 | — | — | WO | disclosed |