Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 6/20 | 0.83 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.81 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.81 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.81 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.81 |
| ▸ | SRC | P12931 | 4/20 | 0.67 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.67 |
| ▸ | MUSK | O15146 | 1/20 | 0.67 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.67 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.67 |
| ▸ | ABL1 | P00519 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | RAF1 | P04049 | 1/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.67 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.67 |
| ▸ | PRKCB | P05771 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693190 | 0.92 | MAPK14 (0.84) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL294966 | 0.91 | TNF (1.00) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL29594348 | 0.91 | TNF (1.00) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6691191 | 0.90 | MAPK14 (0.89) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6694382 | 0.89 | MAPK14 (1.00) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6696049 | 0.88 | MAPK14 (0.85) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6690947 | 0.87 | MAPK14 (0.83) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6697785 | 0.86 | MAPK14 (0.80) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6688831 | 0.84 | MAPK14 (0.76) | TNFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6693424 | 0.83 | MAPK14 (0.87) | TNFMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113352-A1 | SILYLATED HETEROCYCLYLUREA DERIVATIVES AS CYTOKINE-INHIBITORS | AMEDIS PHARMACEUTICALS LTD. (GB) | 2004-12-29 | — | — | WO | disclosed |