Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.60 |
| ▸ | CCR1 | P32246 | 14/20 | 0.59 |
| ▸ | FPR3 | P25089 | 1/20 | 0.59 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077539 | 1.00 | PTGDR2 (0.60) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6077776 | 0.90 | PTGDR2 (0.61) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6077291 | 0.90 | CCR1 (0.61) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6077296 | 0.90 | CCR1 (0.61) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6078449 | 0.89 | CCR1 (0.56) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6076478 | 0.86 | PTGDR2 (0.76) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL5060610 | 0.81 | CCR1 (0.66) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6077904 | 0.79 | CCR1 (0.67) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6077372 | 0.78 | CCR1 (0.56) | PTGDR2CCR1FPR3GPR65GPR35 | |
| SCHEMBL6077065 | 0.77 | CCR1 (0.58) | PTGDR2CCR1FPR3GPR65GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438298-A1 | PIPERAZINE DERIVATIVES WITH CCR1 RECEPTOR ANTAGONIST ACTIVITY | Pfizer Products Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003035627-A1 | PIPERAZINE DERIVATIVES WITH CCR1 RECEPTOR ANTAGONIST ACTIVITY | PFIZER PRODUCTS INC. (US) | 2003-05-01 | — | — | WO | disclosed |