Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471012 | 0.89 | POLB (0.42) | POLBMAPK14TP53MAPTMAPK13 | |
| SCHEMBL6691983 | 0.86 | POLB (0.40) | POLBMAPK14TP53MAPTMAPK13 | |
| SCHEMBL1341271 | 0.84 | POLB (0.43) | POLBMAPK14TP53MAPTMAPK13 | |
| SCHEMBL6695971 | 0.83 | MAPK14 (0.39) | MAPK14MAPTMAPK13NPSR1 | |
| SCHEMBL1340384 | 0.83 | POLB (0.43) | POLBMAPK14TP53MAPTMAPK13 | |
| SCHEMBL1343304 | 0.82 | POLB (0.46) | POLBTP53MAPTMAPK13CSF1R | |
| SCHEMBL1340838 | 0.81 | POLB (0.43) | POLBMAPK14TP53MAPTMAPK13 | |
| SCHEMBL6693383 | 0.81 | POLB (0.41) | POLBMAPK14TP53MAPTMAPK13 | |
| SCHEMBL6692157 | 0.81 | MAPK14 (0.37) | MAPK14MAPK13 | |
| SCHEMBL1343227 | 0.81 | SMN1; SMN2 (0.48) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122235-A1 | Aryl carbonyl derivatives as therapeutic agents | VTV THERAPEUTICS LLC | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122235-A1 | Aryl carbonyl derivatives as therapeutic agents | GCK, GCKR, PDK2 | POLB 3676/4885MAPK14 1028/4885TP53 2961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.