Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 10/20 | 0.61 |
| ▸ | GAA | P10253 | 10/20 | 0.61 |
| ▸ | SI | P14410 | 10/20 | 0.61 |
| ▸ | MGAM2 | Q2M2H8 | 10/20 | 0.61 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11498857 | 0.88 | MGAM (0.65) | MGAMGAASIMGAM2ABL1 | |
| Water SCHEMBL11498856 | 0.86 | MGAM (0.62) | MGAMGAASIMGAM2ABL1 | |
| SCHEMBL12549065 | 0.84 | ABL1 (0.62) | MGAMGAASIMGAM2ABL1 | |
| SCHEMBL6058633 | 0.79 | MGAM (0.60) | MGAMGAASIMGAM2 | |
| SCHEMBL28094886 | 0.79 | BACE1 (0.55) | MGAMGAASIMGAM2ABL1 | |
| SCHEMBL17930919 | 0.79 | CNR2 (0.50) | CNR2ACHEPDE4APDE4BPDE4C | |
| Ether SCHEMBL10542851 | 0.78 | MGAM (0.54) | MGAMGAASIMGAM2ESR2 | |
| SCHEMBL18308823 | 0.77 | ESR2 (0.57) | MGAMGAASIMGAM2ABL1 | |
| SCHEMBL17754363 | 0.76 | MGAM (0.81) | MGAMGAASIMGAM2 | |
| SCHEMBL10542854 | 0.74 | MGAM (0.50) | MGAMGAASIMGAM2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109896919-A | A kind of method that photocatalysis one-step method prepares Bibenzyl compound | 中国科学院大连化学物理研究所 | 2019-06-18 | — | — | CN | disclosed |
| WO-2016001224-A1 | NOVEL ACTIVATORS OF AMP-ACTIVATED PROTEIN KINASES | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2016-01-07 | — | — | WO | disclosed |
| US-6794415-B2 | Biphenyl compounds and their use as oestrogenic agents | AVENTIS PHARMA S.A. (FR) | 2004-09-21 | — | — | US | disclosed |
| US-20040043993-A1 | Biphenyl compounds and their use as oestrogenic agents | AVENTIS PHARMA S.A. | 2004-03-04 | — | — | US | disclosed |
| US-6563008-B2 | Treatment of disorders linked to hypofolliculinemia and of certain estrogen-dependent pathologies such as prostatic adenomas or carcinomas, and of benign tumours of the breast | AVENTIS PHARMA S.A. (FR) | 2003-05-13 | — | — | US | disclosed |
| US-20020068736-A1 | Biphenyl compounds and their use as oestrogenic agents | LESUISSE DOMINIQUE (FR) | 2002-06-06 | — | — | US | disclosed |
| US-6288126-B1 | Biphenyl compounds and use thereof as oestrogenic agents | AVENTIS PHARMA S.A. | 2001-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068736-A1 | Biphenyl compounds and their use as oestrogenic agents | ESR2, ESR1, CYP19A1 | MGAM 4441/4885GAA 3888/4885SI 3894/4885 |
| US-20040043993-A1 | Biphenyl compounds and their use as oestrogenic agents | CYP19A1, HSD17B11, GPER1 | MGAM 4752/4885GAA 3526/4885SI 3679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.