Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460269 | 0.83 | GSK3B (0.70) | GSK3BHDAC1HDAC2HDAC8CDK2 | |
| SCHEMBL1460369 | 0.81 | GSK3B (0.74) | GSK3BHDAC1HDAC2HDAC8CDK2 | |
| SCHEMBL27604440 | 0.81 | GSK3B (0.74) | GSK3BHDAC1HDAC2HDAC8CDK2 | |
| SCHEMBL6478310 | 0.79 | GSK3B (0.64) | GSK3BAURKBSTK17AHDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL6477736 | 0.78 | GSK3B (0.65) | GSK3BHDAC1HDAC2HDAC8CDK2 | |
| SCHEMBL27604435 | 0.77 | GSK3B (0.61) | GSK3BAURKBSTK17AHDAC1HDAC2 | |
| SCHEMBL1461244 | 0.76 | GSK3B (0.76) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL1461358 | 0.76 | GSK3B (1.00) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL6491225 | 0.75 | GSK3B (0.82) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL6491066 | 0.74 | FGFR1 (0.67) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487804-A2 | AMINOINDAZOLE DERIVATIVES AS PROTEIN-KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078403-A2 | DERIVES D’AMINOINDAZOLES COMME INHIBITEURS DE PROTEINE-KINASE | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |