Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.80 |
| ▸ | CX3CR1 | P49238 | 14/20 | 0.80 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6704360 | 0.98 | CXCR2 (0.80) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842206 | 0.94 | CXCR2 (0.86) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842338 | 0.93 | CXCR2 (0.88) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842205 | 0.92 | CXCR2 (0.86) | CXCR2CX3CR1HTR1B | |
| SCHEMBL5438905 | 0.91 | CXCR2 (0.85) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841883 | 0.89 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841882 | 0.89 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B | |
| SCHEMBL213765 | 0.87 | CXCR2 (1.00) | CXCR2CX3CR1 | |
| SCHEMBL841954 | 0.86 | CXCR2 (0.98) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841943 | 0.85 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224961-A1 | Novel thiazolo (4,5-D) pyrimidine compounds | ASTRAZENECA UK LIMITED, A BRITISH CORPORATION | 2004-11-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224961-A1 | Novel thiazolo (4,5-D) pyrimidine compounds | TYMS, DPYD, TYMP | CXCR2 378/4885CX3CR1 2551/4885HTR1B 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.