SCHEMBL6708750

SCHEMBL6708750

N#Cc1ccc(Cn2cncc2CNC(c2ccc(N3CCN(C(=O)c4ccc(Cl)s4)CC3)cc2)c2ccsc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FNTA P49354 7/20 0.46
FNTB P49356 7/20 0.46
PGGT1B P53609 5/20 0.43
KCNH2 Q12809 1/20 0.41
CYP11B1 P15538 2/20 0.40
CYP11B2 P19099 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6711221 0.90 FNTA (0.46) FNTAFNTBPGGT1BKCNH2
SCHEMBL6708752 0.85 FNTA (0.46) FNTAFNTBPGGT1B
SCHEMBL6708779 0.85 FNTA (0.51) FNTAFNTBPGGT1B
SCHEMBL6708756 0.80 FNTA (0.45) FNTAFNTBPGGT1BKCNH2
SCHEMBL6710993 0.79 FNTA (0.49) FNTAFNTBPGGT1BCYP11B1CYP11B2
SCHEMBL6709664 0.79 FNTA (0.49) FNTAFNTBPGGT1BCYP11B1CYP11B2
SCHEMBL6709693 0.79 FNTA (0.47) FNTAFNTBPGGT1BCYP11B1CYP11B2
SCHEMBL6710804 0.79 FNTA (0.47) FNTAFNTBPGGT1B
SCHEMBL6710802 0.79 FNTA (0.45) FNTAFNTBPGGT1B
SCHEMBL6711141 0.79 FNTA (0.45) FNTAFNTBPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092524-A1 Novel aminophenyl piperazine or aminophenyl piperidine derivatives inhibiting prenyl transferase proteins and method for preparing same PIERRE FABRE MEDICAMENT (FR) 2004-05-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092524-A1 Novel aminophenyl piperazine or aminophenyl piperidine derivatives inhibiting prenyl transferase proteins and method for preparing same CBR3, CBR1, HCCS FNTA 194/4885FNTB 48/4885PGGT1B 1175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.