Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.59 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2414505 | 1.00 | SPHK2 (0.59) | SPHK2SPHK1GPR84FFAR1FFAR4 | |
| SCHEMBL2410487 | 1.00 | — | — | |
| SCHEMBL7353606 | 1.00 | SPHK2 (0.59) | SPHK2SPHK1GPR84FFAR1FFAR4 | |
| SCHEMBL3909714 | 0.97 | — | — | |
| SCHEMBL2926097 | 0.88 | — | — | |
| SCHEMBL23668354 | 0.87 | SPHK2 (0.72) | SPHK2SPHK1LMNAALDH1A1MEN1 | |
| SCHEMBL17747405 | 0.87 | SPHK2 (0.72) | SPHK2SPHK1LMNAALDH1A1MEN1 | |
| SCHEMBL31541184 | 0.87 | SPHK2 (0.72) | SPHK2SPHK1LMNAALDH1A1MEN1 | |
| SCHEMBL31541186 | 0.87 | SPHK2 (0.72) | SPHK2SPHK1LMNAALDH1A1MEN1 | |
| SCHEMBL11154443 | 0.87 | SPHK2 (0.72) | SPHK2SPHK1LMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |