Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.69 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.69 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882181 | 0.95 | GRIA1 (0.77) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| SCHEMBL1879835 | 0.93 | GRIA1 (0.80) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| SCHEMBL1882173 | 0.88 | GRIA1 (0.76) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| SCHEMBL1882146 | 0.85 | GRIA1 (0.80) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| SCHEMBL1883212 | 0.84 | GRIA1 (0.67) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| SCHEMBL1883286 | 0.84 | GRIA1 (0.75) | GRIA1GRIA3PDE4DGRM5TDP2 | |
| Perampanel SCHEMBL194370 | 0.83 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| Perampanel SCHEMBL4214584 | 0.83 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| Perampanel SCHEMBL2857277 | 0.83 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5GABRA1 | |
| Perampanel SCHEMBL31069847 | 0.83 | GRIA1 (1.00) | GRIA1GRIA3PDE4DGRM5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |